Job Description

Our large pharmaceutical clients is seeking a Scientist for Protein Biophysical Analysis to join their growing Binding Group in Spring House, PA. This team focuses on the development and application of preclinical assays in support of the discovery of therapeutic candidates. This individual will be responsible for the application of technologies for biophysical and biochemical characterization and is responsible for implementing methods for affinity analysis. The scientist works under minimal supervision exercising autonomy. Other responsibilities include:

• Kinetics and affinity analysis of antigens and antibodies using SPR, BLI and KinExA.
• Perform HPLC analyses to assess the hydrophobicity, size, and purity of proteins.
• Characterization of molecules using mass spectrometry (MS).
• Data analysis, Documentation, and reporting – ELNs, LIMS etc.,
• Lab instrument maintenance – cleaning spray sources and calibration weekly, prepping calibration solutions.
• Support assay development, validation, and bioanalysis efforts, as needed.
• Assist in drafting and executing peer reviewed posters, manuscripts, tech reports and patent filings.

Qualifications:

• Minimum of a Bachelor’s Degree in a related field of study
• Experience in Biophysical Binding analysis methods (e.g., Biacore, LSA, Other SPR methods (e.g Proteon) BLI (Octet), KinExA, Fluorescence anisotropy, RIA, or Flow cytometry affinity focused on affinity determination)
• Solid understanding of protein biochemistry, binding affinity, thermodynamics, and antibody structure is preferred.
• Pharmaceutical experience with mass spectrometry characterization of antibodies is preferred

Salary: $75,000-$90,000 (flexible based on experience)

Hours: Monday-Friday, 8:00am-5:00pm

Hiring Method: Multiyear contract – After 1 year on contract, the individual will have the opportunity to apply for a permanent role or have their contract renewed for another year

PTO : 10 PTO days, 6 paid sick days annually & paid Holidays

Benefits: Medical, Dental, Vision and 401K plans available

Exact compensation may vary based on several factors, including skills, experience, and education. Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.

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